Free chemistry book: Organic synthesis wordbook 1,2,3
1.Oranic synthesis workbook I:
The
Organic Synthesis Workbook promises to be to the current generation of graduate students, and even “students-for-life”, what Ireland’s and Alonso’s
books were to those of us who were graduate students in the 80’s Alsono: The Art of Problem Solving in
Organic Chemistry, Ireland:
Organic Synthesis.
We hope you’lI find working with this problem book to be an enjoyable
experience!
A wonderful tradition in the research group of Prof. L. F. Tietze
at the University of Gbttingen is a seminar entitled Problems. This
seminar provides the opportunity in a relaxed, conversational setting
for participants to rack their brains over natural-product syntheses
presented to them in tantalizingly fragmentary formo No holds
are barred when it comes to questions that rnight be raised!
Insofar as possible we have attempted to recreate that same atmosphere
in our exercise book.
The book is directed toward advanced students of organic chemistry
– graduate and undergraduate – who have a special interest in synthesis.
The subject matter is distributed over 16 mutually independent
chapters in such a way as to encourage individual study, but the solitary
reader is never left entirely at the mercy of his or her own ingenuity
as far as solving the problems is concemed.
Each chapter begins with a brief Introduction, which serves
mainly to acquaint the reader with the nature and origin of the current
target molecule. This is followed by a double-page spread, the
Overview, which outlines the various challenges posed in that particular
chapter, setting them within the context of an overall reaction
scheme. Already at this point the interested reader can begin
dealing with a fresh set of puzzles drawn from an imaginative and
timely total synthesis of a complex organic molecule.
Every Overview is followed by a detailed section entitled Synthesis,
where each individual problem is examined, beginning with its
restatement in the form of the appropriate chemical equation set
against a gray background for emphasis. Each problem is characterized
by an interesting gap that must be bridged: a rnissing starting
material, product, or set of essential reagents. If reagents and reaction
conditions are to be elucidated, the corresponding equation arrow
will lack the customary explanatory labe!’ Sometimes several
steps are grouped together as one problem, in which case a clear indication
is provided of the number of operations required.
Author:
P. Menningen, T. Nobel, H. Schirock, C. Wulff
1. A. Gewert, 1. Gorlitzer, S. Gotze, 1. Looft
Foreword by Erick M. Carreira
Contents
Chapter 1: Veticadinol (Tietze 1988)
Chapter 2: (±)-Mamanuthaquinone (Danishefsky 1994)
Chapter 3: (-)-Swainsonine (Pearson 1996)
Chapter 4: (-)-L19(12)-Capnellene (Shibasaki 1996)
Chapter 5: (-)-Epothilone A (Shinzer 1997)
Chapter 6: Erythronolid A (Hoffmann 1993) 77
Chapter 7: Tautomycin (Armstrong 1996)
Chapter 8: (-)-a-Thujone (Oppolzer 1997)
Chapter 9: (+)-Camptothecin (Ciufolini 1996)
Chapter 10: (-)-Cephalotaxin (Mori 1995)
Chapter 11: (+)-Streptazolin (Kibayashi 1996)
Chapter 12: Amyrin (Corey 1993)
Chapter 13: (+)-Asirnicin (Hoye 1995)
Chapter 14: (Z)-Dactomelyn (Lee 1995)
Chapter 15: Maehr’s Roflamycoin (Rychnovsky 1994)
Chapter 16: Fluvirucin-B1-Aglycone (Hoveyda 1995)
2.Oranic synthesis workbook II:
Organic chemistry is easy to teach but difficult to learn. Students often complain that they
understand the lectures or the book but ‘can’t do the exam questions’. This is largely because of
the unique nature of the subject – at once more unified than any other branch of chemistry (or of
science?) and more diverse in its applications. Research workers similarly often feel they
understand the basic principies of the subject but fail to find a solution to a problem even though
they understand their molecules very well. All organic chemists need to match intellectuallearning
with the skill to deal with the difficulty of the moment.
The answer to these dilemmas is problem solving. Or more exactly solving invented
problems on paper at the same time as mastering the intellectual understanding. Now a new
difficulty arises. Where is one to find a carefully graded set of problems arranged around a
comprehensible framework that gives significance to the answers by showing that solving these
problems is practical and useful? It is not easy to compile such a set of problems. 1 know, as 1
wrote both the problems in our recent textbook and the solutions manual.
Organic Synthesis Workbook II will be the answer to many young organic chemists’
prayers. It is a set of problems of extraordinary diversity set within the framework of large
syntheses. This gives the young authors (all members of Professor Lutz Tietze’s research group at
Gottingen) the freedom to reveal details or to conceal them. The reader might be asked simply to
furnish a reagent for a given step, or more challenging questions like explaining a mechanism or a
stereoselectivity. Even prediction appears as sorne of the intermediates in the big syntheses are
blank spaces to be filled in. The layout is intriguing – one wants to read on, as in the best novels,
first to find out what happens and then to find out how it was done. Needless to say, just turn the
page and the answers appear. And just because you couldn’t do that problem, you’re not
handicapped when it comes to the next.
You should not suppose that this book is simply about organic synthesis. It has a lot to
offer to the general student of organic chemistry at the advanced undergraduate and graduate level.
The problems vary in difficulty but there is something to suit us all. The rewards of tackling the
problems seriously will be great. 1 am very enthusiastic about this book and 1 know a lot of readers
will share my enthusiasm.
We have not changed the proved original concept, and therefore we hope that those who already
know Organic Synthesis Workbook will feel at home.
This book contains 16 independent chapters, based on publications of well known scientists.
Each chapter is divided into five parts. First, the Introduction will give you a brief view of the
target molecule and its background. The Overview shows the complete synthetic problem on two
pages. In the Synthesis section the reaction sequence is divided ¡nto individual Problems.
Afterwards Hints are given to assist you in solving the problem. Each further hint will reveal more
and more of the solution; therefore it might be useful to cover the remaining page with a piece of
paper. The Solution will show if your answer is correct. In the Discussion section the problem is
explained in detail. However this book cannot serve as a substitute for an organic textbook. After
the last problem, the Conclusion briefly comments on the synthesis, highlighting the key steps.
The original references can be found in the Literature section for further reading.
Author:
Gewert, J.A./Gorlitzer, J./
Gotze, S./Looft, J./Menningen, P./
Nobel, T./Schirok, H./Wulff, C.
Organic Synthesis Workbook
2000. ISBN 3-527-30187-9
Constable, E.C
Metals and Ligand Reactivity
An Introduction to the Organic Chemistry of Metal Complexes
1996.308 pp. ISBN 3-527-29278-0
Ansari, F. L./Qureshi, R./Qureshi, M.L.
Electrocyclic Reactions
From Fundamentals to Research
1998.288 pp. ISBN 3-527-29755-3
Lehn, J.-M.
Supramolecular ChemistryConcepts and Perspectives
1995. 2881JJp. ISBN 3-527-29311-6
Waldmann, H./Mulzer, J. (eds.)
Organic Synthesis Highlights 111
1998. ISBN 3-527-29500-3
Nicolaou, K.C/Sorensen, E.J.
Classics in Total Synthesis1996. ISBN 3-527-29231-4
Hopf, H.
Classics in Hydrocarbon Chemistry
Syntheses, Concepts, Perspectives
2000. ISBN 3-527-29606-9
Lindhorst, T.K.
Essentials of Carbohydrate Chemistry
and Biochemistry
2000. ISBN 3-527-29543-7
https://www.facebook.com/Chemistry.and.pharmacy
3.Oranic synthesis workbook III:
Organic synthesis is at the heart of chemistry. Although today interdisciplinary areas between
chemistry and biology or between chemistry and material sciences are ofien believed to provide
the main driving forces for the advancement of chemistry, I am convinced that the development
of efficient and environmentally benign synthetic methods is still one of the most important goals
of current chemical research. Significantly, a majority of all chemists doing research in industry
or academia are faced in their daily lives with demands for the efficient synthesis of new
molecules. It is thus important to attract the interest of talented students for this area and to
provide high quality education. From the beginning, the Organic Synthesis Workbook has been
devoted to a significant extent to the training and education of students and younger researchers
in this direction. The main concept is to present challenging synthetic problems to the reader,
which are selected from state-of-the-art syntheses of natural products. The present 3rd volume
successfully follows this track.
The new Organic Synthesis Workbook – similar to its predecessors – has been carefully devised
and realized by a group of creative young students from the Institute of Organic and Biomolecular
Chemistry ofthe Georg-August-University ofGottingen, Germany.1t covers 14 wellselected
synthetic problems including modern catalytic coupling reactions and metathesis
chemistry, together with recent developments in stereoselective carbon-carbon and carbonoxygen
bond formation. More specifically, each problem is introduced to the reader in a general
marmer. Afier this introduction the key chemistry of the respective synthesis is explained. Then,
the various synthetic problems are presented in a clear and understandable manner. The major
difference to classical teaching books is the active interaction ofthe reader with the content.
One could ask, is the concept ofthis book still timely? In my opinion, definitely yes! Obviously,
information pours out from all kinds of scientific journals, PowerPoint presentations, and
especially the internet. However, to acquire long-Iasting knowledge of organic synthesis, and to
transfer this knowledge, it is essential not only to consume facts and data but to apply it to real
synthetic problems. Thus, in addition to students for Masters and PhD degrees, everyone
interested in synthetic chemistry is encouraged to train actively with books such as this.
Finally, 1 wish to congratulate the authors for their excellent achievement. It remains for me to
hope that readers will enjoy working with this volume and discover aspects that will stimulate
their own future research
